Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR

Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR

Blog Article

Epistasis effects LAUNDRY BASKET among amino acids at distal sites within binding pockets can have important impacts on Straining Bag protein fitness landscapes.Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.